Hair Restoration - PRP
 
Platelet-Rich Plasma (PRP) is an established injection therapy to enhance tissue regeneration.

Used in orthopaedics and sports medicine, PRP treatment is now increasingly used to stimulate hair regrowth. PRP is defined as an autologous concentrated preparation of platelets and their associated growth factors in a small volume of plasma.
What is PRP?

PRP (Platelet Rich Plasma) is blood plasma containing a high concentration of platelets. These platelets are considered a biochemical storehouse of growth factors that participate in recovery and healing of the hair follicle, as well as prolonging the phase of the hair growth cycle and, in some cases, thickening the hair.

Treatment
A small amount of your blood is taken. It is then centrifuged to separate red blood cells from the plasma containing the growth factor within the platelets. This clear golden plasma is then injected into your scalp near the surface where it is needed. There should be little or no discomfort. A trained specialist will advise you on the best approach and the treatment path.

The PRP treatment uses growth factors found in your own blood to regenerate your hair growth. A natural approach to hair restoration.

For hair regrowth, the technique comprises withdrawal of the patient's own blood (11ml, 22ml or 44ml) processing of the latter according to the manufacturer instructions for use, to separate blood components (Platelet-Rich Plasma, Platelet-Poor Plasma, Red and White Blood Cells) and the injection of PRP to the treated site. The whole procedure takes up to 1 hour.

Generally an initial 3 treatments one month apart are advised with the possibility of a fourth treatment.  Your doctor will then assess your treatment. This treatment protocol may vary according to different patient unique parameters such as age, baseline condition as a result of smoking, diet, genetics and other factors. Maintenance is advised (as a single session)  once or twice a year subsequently.

Benefits of PRP therapy in Hair Loss
More research is being released every day regarding the effectiveness of PRP for hair loss, including some medical hair loss problems that otherwise don't have a good solution.
The procedure does not create new hair follicles, instead, the procedure stimulates follicles that are not strong enough to provide hair but are not yet dead.    PRP is considered to be a good option for patients who do not want a hair transplantation procedure, or if used as an adjunct to hair transplants and other topical treatments.

Nothing is absolutely guaranteed in medicine.  PRP has its place in the treatment of hair loss as a natural alternative to anti-androgenic medicine.  PRP treatment makes use of growth factors found within platelets in one's own blood.  The injections are a successful therapy for many people; everyone will show a positive response, it is a question of how much hair you will grow.

PRP hair restoration treatments are suitable for treating male and female hair loss.

Safety of PRP Treatment
PRP treatment is autologous (derived from the patient's own blood), minimizing safety concerns for allergic response or disease transmission. PRP may be combined with other treatments to stimulate its biological effect.

Results
Since PRP stimulates a biological effect, results should not be expected immediately and are generally visible at 3-4 weeks, with continuous gradual improvement over 6-12 months. Improvement is dependent on follicle conditions, and the initial cause of hair loss.

Current evidence shows clinical improvement in the mean number of hairs, with a mean increase of 33.6% hairs in the target area and a mean increase in total hair density of 45.9% hairs per cm2 compared with baseline values. [Ref 1]

[Ref 1]  The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial
Gentile et al.  Stem Cells Transl Med. 2015 Nov; 4(11): 1317–1323.

Contraindications
Contraindications include platelet dysfunction syndrome, critical thrombocytopenia, hemodynamic instability, septicemia, local infection at the site of the procedure, pregnancy, breast feeding, urticaria, and cancer. Consistent use of NSAID drugs within 48 hours of PRP application should be avoided.
Side effects and Risks

The autologous nature of PRP minimizes concerns for disease transmission. Possible side effects are due to the injection process itself and the use of local anaesthetic. These may include skin redness, mild bruising, bleeding, pain or itching at the injection site, swelling, allergic reaction to the solution, infection, damage to a nerve or muscle, headache, nausea, vomiting , dizziness or fainting .
  











 






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PRP HAIR RESTORATION SUMMARY
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Recovery Time: 0 – 1 days

Treatment time: Approximately 1 hour / session

Number of treatments: typically 1 to 3 


Suitable for treating both Male and Female hair loss / thinning

Session cost:  £380 for a single session or £920 for 3 sessions

Course advised: Yes. Number of sessions depends on the extent and  cause of hair loss



  
FREQUENTLY ASKED QUESTIONS

Q:    Why Is PRP effective in promoting Hair Restoration?
A:   The use of PRP is a great treatment option for hair loss because it has a number of scientifically based articles, showing its efficacy in increasing hair count, hair thickness and the growth phase of the hair cycle.
Current evidence shows clinical improvement in the mean number of hairs, with a mean increase of 33.6% hairs in the target area and a mean increase in total hair density of 45.9% hairs per cm2 compared with baseline values. 1

1 The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial
Gentile et al.  Stem Cells Transl Med. 2015 Nov; 4(11): 1317–1323.

PRP serves to promote the growth of hair by stimulating the stem cells located in the dermal papilla along with the other cell structures present in the hair follicle.   PRP cannot cause growth of new hair follicles once they have died or where they have not existed before.

The PRP specific growth factors or proteins that induce hair growth include:
Platelet-Derived Growth Factor (PDGF) – promotes blood vessel growth, cell replication & skin formation
Vascular Endothelial Growth Factor (VEGF) – promotes blood vessel formation
Epidermal Growth Factor (EGF) – promotes cell growth and differentiation, blood vessel formation and collagen formation
Fibroblast Growth Factor – 2 (FGF-2) – promotes growth of specialized cells and blood vessel formation
Insulin-like Growth Factor – (IGF) – a regulator of normal physiology in nearly every type of cell in the body

Q: Is thinning hair only a male problem?
A: No.  There are many women who experience hair thinning and loss. According to the International Society of Hair Restoration Surgery (SHRS), almost 40% of people experiencing hair loss are women. The psychological impact of hair loss may be even more alarming for women than it is for men.
There are many reasons why women also suffer hair loss, and it is often more than one cause at any one time.  These include hormonal fluctuations, such as post pregnancy shedding, menopause-related hair loss, starting or stopping some forms of contraception, underlying hormonal imbalances such as polycystic ovary syndrome (PCOS). In addition, over processing the hair with heat and chemical styling or wearing hairstyles that pull on the hair can also cause weathering, hair breakage, and traction hair loss.

Q: Is thinning hair only experienced when you’re older?
A: While most people associate hair loss and balding with older people, it happens to young ones as well. If there are others in the family who have experienced it, then it may not be such a shock. But for those younger people who haven’t seen other family members experience it, balding at a young age can cause a lot of psychological stress.


Q: Do hats or frequent shampooing make your hair fall out?
A: While hats and shampooing don’t lead to hair loss, it can be a problem if you are wearing hats too tight, or not keeping them clean. Some of the things people do to their hair can lead hair to fall out, including pulling the hair too tightly, such as in pigtails, as well as using hot oil treatments, which can lead to the hair follicles becoming inflamed.

Q:  Is stress the only cause of hair loss?
A: Hair loss can happen for many reasons. Some of the reasons can be diabetes, lupus, poor nutrition, thyroid problems, medications, and other health conditions. High-stress levels can be a contributing factor to hair loss, but the most common reason is genetics.

Q:  Does shaving makes the hair grow back thicker.
A: Shaving doesn’t make the hair grow back thicker. If that worked, everyone losing their hair could simply shave it and wait for it to grow back thicker and fuller.

Q:  Isn’t hair regeneration treatment time-consuming and inconvenient.
A: Hair restoration services are easier and more convenient than ever today. Recent advances such as Cellenis PRP can generate results in as little as 30 minutes treatment time.

PRP treatment can be performed as a standalone treatment or can be combined with transplant surgery. Since PRP is an injection therapy, patients generally return to work the same or the next day.   
The best advice for men and women with thinning or balding hair is to get a consultation. Then they will have the answers to why they are losing their hair and what options there are to do something about it.
  
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